Tektonyx Bio is focused on the use and optimization of a semi-synthetic E. coli organism for the production of novel protein therapeutics. We harness the power of a revolutionary technology based on E. coli that has been engineered to utilize an expanded genetic alphabet composed of the four natural nucleotides and two additional, synthetic nucleotides. This technology allows the encoding and production of custom proteins with site-specific functionalities for the discovery and development of novel protein-based therapeutics. We are seeking an analytical scientist/mass spectrometrist to utilize and help develop novel analytical, proteomic, and metabolomic methods to optimize unnatural protein production as well as to further optimize the semi-synthetic organism.
Key Responsibilities
Ability to serve as the analytical subject matter expert and work closely with colleagues across the company.
Develop chromatography and mass spectrometry methods for characterizing the expressed proteins and assessing expression yields and the fidelity with which various non-canonical amino acids are incorporated.
While use of the semi-synthetic organism for industrial scale therapeutic protein production has been validated, many aspects of the organism’s physiology remain to be further optimized, and the successful applicant will work with colleagues focused on optimizing the organism’s physiology. This will include both metabolomics and proteomics.
Tektonyx Bio places a premium on intra-company collaboration, and thus the desire to interact closely with all facets of the effort to develop and use the semi-synthetic organism for novel therapeutic protein production is a must. The successful applicant should also enjoy and excel at working collaboratively on fast paced projects with rapidly evolving goals.
Basic Qualifications
PhD in a field related to analytical chemistry, proteomics, or metabolomics. Additional postdoctoral/industry experience is a benefit but not a requirement.
Strong background in chromatographic separation, biophysical characterization (SPR, DLS, DSF, circular dichroism), and spectrophotometric techniques for proteins and protein conjugates. Familiarity with Agilent instrumentation (LC & Q-TOF LC/MS) and OpenLab/Chromeleon software is a benefit.
Familiarity with the routine use of mass spectrometry for the characterization of proteins is essential. Familiarity with the use of mass spectrometry proteomics/metabolomics is beneficial, but not essential.
Excellent written and oral communication skills; strong organizational skills and attention to detail.
The salary range for this role is $120,000 – $160,000 and is based on a number of factors including qualifications and experience. Tektonyx also offers a comprehensive benefits package. To apply for this position, submit a resume and cover letter describing your experience, interests, why you are interested in joining us, and any other information that you would consider relevant to careers@tektonyxbio.com
...Juniors, Seniors and Graduate students seeking business, science, and software development opportunities that provide... ...meaningful work experience to be a part of our 2025 Intern class. Learn and apply state-of-the-art data science practices as a member of an...
...2200 Corporate Location- Clark International is seeking a professional, self-motivated, dependable candidate for a private security position in a corporate environment. Applicants must have pistol certification in congruence with Certified LE pistol qualification...
...newly licensed and ready to launch your real estate career with the right team? Were looking... ...and ready to take your career to the next level, wed love to hear from you. Apply today... ...Qualifications: To be considered for the role of Entry-Level Real Estate Sales Agent in San...
...education platform, available on any mobile device, that includes: Quick access to drug information, patient education and more Animations, videos and illustrations of procedures Updates on best practices Online assigned tasks and training Continuity of Care:...
...Job Title: Commercial HVAC Chiller Technician Location: Seattle, WA Job Summary We are seeking an experienced and highly skilled Commercial... ...is ideal for a technician with a strong background in servicing, maintaining, and repairing commercial HVAC systems...